Enable the App-ID cache for Network Packet Broker.
Verify
the settings show that 
Application cache is
set to 
yes and 
Use cache for appid is
set to 
yes: 
admin@PA-3260> show running application setting
Application setting:
Application cache             : yes
Supernode                     : yes
Heuristics                    : yes
Cache Threshold               : 1
Bypass when exceeds queue limit: no
Traceroute appid              : yes
Traceroute TTL threshold      : 30
Use cache for appid           : yes
Use simple appsigs for ident  : yes
Use AppID cache on SSL/SNI    : no
Unknown capture               : on
Max. unknown sessions         : 5000
Current unknown sessions      : 33
Application capture           : off
Current APPID Signature
   Memory Usage               : 16768  KB (Actual 16461  KB)
      TCP 1 C2S               : regex 11898  states
      TCP 1 S2C               : regex 4549   states
      UDP 1 C2S               : regex 4263   states
      UDP 1 S2C               : regex 1605   states