On Prisma Access 5.2.1 Innovation (dataplane 11.2.4), if you select Action for sites that cannot be decrypted (technical or policy reason)Block for RBI and select DeviceSSL Decryption SettingsSend handshake messages to CTD for inspection in Panorama, isolated browsing won't work correctly.

Workaround: Set Action for sites that cannot be decrypted (technical or policy reason) to Allow.

RBI supports only 64-bit web browsers. 32-bit web browsers are not supported.

Accessibility functions provided by web browsers, such as the read aloud function, are not supported in RBI.

When navigating to a nonisolated URL, the webpage won't load correctly if the subresources on the webpage match a security rule with isolation. As a workaround, you need to configure your security rules to allow subresource URLs. To do this, update your URL access Management Profile to set the site access for the subresource URL to Allow.

Depending on their implementation, some browser extensions on an end user's local browser that interact with a loaded page will be ignored (won't take effect) during remote isolated browsing. For example, ad blockers installed on a local browser don't take effect during local browsing. Extensions that don't interact with a webpage will still work in isolated browsing.

While downloading content during isolated browsing, if RBI does not receive the Content-Length header in an HTTP request or response, the download percentages won’t display accurately.